Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.

Jehan, Zeenath; Bavi, Prashant; Sultana, Mehar; Abubaker, Jehad; Bu, Rong; Hussain, Azhar; Alsbeih, Ghazi; Al-Sanea, Nasser; Abduljabbar, Alaa; Ashari, Luai H; Alhomoud, Samar; Al-Dayel, Fouad; Uddin, Shahab; Al-Kuraya, Khawla S

Jehan, Zeenath; Bavi, Prashant; Sultana, Mehar; Abubaker, Jehad; Bu, Rong; Hussain, Azhar; Alsbeih, Ghazi; Al-Sanea, Nasser; Abduljabbar, Alaa; Ashari, Luai H; Alhomoud, Samar; Al-Dayel, Fouad; Uddin, Shahab; Al-Kuraya, Khawla S.

Affiliation

Jehan Z; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

J Pathol ; 219(3): 337-46, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19697359

Subject(s)

Biomarkers, Tumor/genetics; Colorectal Neoplasms/genetics; Gene Amplification; Phosphatidylinositol 3-Kinases/genetics; Adenoma/genetics; Adenoma/metabolism; Adenoma/pathology; Adult; Aged; Biomarkers, Tumor/metabolism; Chemotherapy, Adjuvant; Class I Phosphatidylinositol 3-Kinases; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Colorectal Neoplasms/therapy; Epidemiologic Methods; Female; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Oligonucleotide Array Sequence Analysis/methods; Phosphatidylinositol 3-Kinases/metabolism; Prognosis; Radiotherapy, Adjuvant; Reverse Transcriptase Polymerase Chain Reaction/methods; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Biomarkers, Tumor / Gene Amplification / Phosphatidylinositol 3-Kinases Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Pathol Year: 2009 Document type: Article Affiliation country: Saudi Arabia Country of publication: United kingdom

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