Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas.

Spada, A; Reza-Elahi, F; Lania, A; Bassetti, M; Atti, E

Spada, A; Reza-Elahi, F; Lania, A; Bassetti, M; Atti, E.

Affiliation

Spada A; Institute of Endocrine Sciences, University of Milan, Italy.

J Clin Endocrinol Metab ; 70(5): 1262-8, 1990 May.

Article in En | MEDLINE | ID: mdl-1970828

Subject(s)

Adenoma/metabolism; Adenylyl Cyclases/metabolism; Adrenocorticotropic Hormone/metabolism; Calcium/metabolism; Corticotropin-Releasing Hormone/pharmacology; Paraneoplastic Endocrine Syndromes/metabolism; Pituitary Neoplasms/metabolism; Somatostatin/pharmacology; Adenoma/enzymology; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Cells, Cultured; Cytosol/drug effects; Cytosol/metabolism; Dose-Response Relationship, Drug; Drug Interactions; Humans; Paraneoplastic Endocrine Syndromes/enzymology; Pertussis Toxin; Pituitary Neoplasms/enzymology; Virulence Factors, Bordetella/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Pituitary Neoplasms / Corticotropin-Releasing Hormone / Somatostatin / Adenoma / Adenylyl Cyclases / Calcium / Adrenocorticotropic Hormone / Paraneoplastic Endocrine Syndromes Limits: Humans Language: En Journal: J Clin Endocrinol Metab Year: 1990 Document type: Article Affiliation country: Italy Country of publication: United States

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