MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.

Miyaki, Shigeru; Nakasa, Tomoyuki; Otsuki, Shuhei; Grogan, Shawn P; Higashiyama, Reiji; Inoue, Atsushi; Kato, Yoshio; Sato, Tempei; Lotz, Martin K; Asahara, Hiroshi

Miyaki, Shigeru; Nakasa, Tomoyuki; Otsuki, Shuhei; Grogan, Shawn P; Higashiyama, Reiji; Inoue, Atsushi; Kato, Yoshio; Sato, Tempei; Lotz, Martin K; Asahara, Hiroshi.

Affiliation

Miyaki S; Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Arthritis Rheum ; 60(9): 2723-30, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19714579

Subject(s)

Cartilage, Articular/metabolism; Chondrocytes/metabolism; Interleukin-1beta/metabolism; MicroRNAs/metabolism; Osteoarthritis, Knee/metabolism; RNA, Double-Stranded/metabolism; ADAM Proteins/metabolism; ADAMTS5 Protein; Adult; Aged; Aged, 80 and over; Aggrecans/metabolism; Cartilage, Articular/pathology; Case-Control Studies; Cells, Cultured; Chondrocytes/drug effects; Chondrocytes/pathology; Collagen Type II/metabolism; Humans; Interleukin-1beta/pharmacology; Mesenchymal Stem Cells/metabolism; Mesenchymal Stem Cells/pathology; Osteoarthritis, Knee/pathology; SOX9 Transcription Factor/metabolism; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Double-Stranded / Cartilage, Articular / Chondrocytes / Osteoarthritis, Knee / MicroRNAs / Interleukin-1beta Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Humans Language: En Journal: Arthritis Rheum Year: 2009 Document type: Article Affiliation country: United States

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