Carbamylated erythropoietin protects the myocardium from acute ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism.

Xu, Xuan; Cao, Zhijuan; Cao, Bin; Li, Jing; Guo, Lin; Que, Linli; Ha, Tuanzhu; Chen, Qi; Li, Chuanfu; Li, Yuehua

Xu, Xuan; Cao, Zhijuan; Cao, Bin; Li, Jing; Guo, Lin; Que, Linli; Ha, Tuanzhu; Chen, Qi; Li, Chuanfu; Li, Yuehua.

Affiliation

Xu X; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Pathophysiology, Nanjing Medical University, Nanjing, China.

Surgery ; 146(3): 506-14, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19715808

Subject(s)

Cardiotonic Agents/therapeutic use; Erythropoietin/analogs & derivatives; Myocardial Reperfusion Injury/metabolism; Myocardial Reperfusion Injury/prevention & control; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Androstadienes/pharmacology; Animals; Cytokine Receptor Common beta Subunit/metabolism; Erythropoietin/therapeutic use; GATA4 Transcription Factor/metabolism; Male; Mice; Mice, Inbred BALB C; Myocardial Infarction/drug therapy; Myocardial Infarction/metabolism; Myocardial Infarction/pathology; Myocardial Reperfusion Injury/pathology; Myosin Heavy Chains/metabolism; Receptors, Erythropoietin/metabolism; Signal Transduction/drug effects; Troponin I/metabolism; Wortmannin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiotonic Agents / Myocardial Reperfusion Injury / Erythropoietin / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt Limits: Animals Language: En Journal: Surgery Year: 2009 Document type: Article Affiliation country: China

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