Design and synthesis of pyridazinone-based 5-HT(2C) agonists.

Allerton, Charlotte M N; Andrews, Mark D; Blagg, Julian; Ellis, David; Evrard, Edel; Green, Martin P; Liu, Kevin K-C; McMurray, Gordon; Ralph, Michael; Sanderson, Vivienne; Ward, Robin; Watson, Lesa

Allerton, Charlotte M N; Andrews, Mark D; Blagg, Julian; Ellis, David; Evrard, Edel; Green, Martin P; Liu, Kevin K-C; McMurray, Gordon; Ralph, Michael; Sanderson, Vivienne; Ward, Robin; Watson, Lesa.

Affiliation

Allerton CM; Department of Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT139NJ, UK. charlotte.allerton@pfizer.com

Bioorg Med Chem Lett ; 19(19): 5791-5, 2009 Oct 01.

Article in En | MEDLINE | ID: mdl-19716297

Subject(s)

Piperazines/chemical synthesis; Pyridazines/chemical synthesis; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists/chemical synthesis; Animals; Dogs; Drug Design; Humans; Piperazines/chemistry; Piperazines/pharmacology; Pyridazines/chemistry; Pyridazines/pharmacokinetics; Pyridazines/pharmacology; Receptor, Serotonin, 5-HT2A/metabolism; Receptor, Serotonin, 5-HT2B/metabolism; Receptor, Serotonin, 5-HT2C/metabolism; Serotonin Receptor Agonists/chemistry; Serotonin Receptor Agonists/pharmacokinetics; Structure-Activity Relationship; Urinary Incontinence, Stress/drug therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyridazines / Serotonin Receptor Agonists / Serotonin 5-HT2 Receptor Agonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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