Gastric delivery system for iron supplementation.
Lancet
; 335(8698): 1136-9, 1990 May 12.
Article
in En
| MEDLINE
| ID: mdl-1971872
ABSTRACT
A gastric delivery system (GDS) for iron supplementation was evaluated. Radioisotopic studies in 9 volunteers demonstrated a three-fold higher absorption of GDS iron compared with ferrous sulphate elixir. A double-blind placebo controlled trial was done in 200 women to compare the gastrointestinal side-effects associated with 50 mg iron daily given either as GDS or conventional ferrous sulphate. The conventional preparation was associated with a significantly higher frequency of nausea and anorexia, whereas there were no significant differences in reported side-effects between subjects receiving GDS or placebo. A single GDS capsule daily provides the same amount of absorbed iron as conventional ferrous sulphate given three times daily, and does not produce gastrointestinal side-effects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ferrous Compounds
/
Gastric Mucosa
/
Anemia, Hypochromic
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Evaluation_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Lancet
Year:
1990
Document type:
Article