Differential cytotoxic effects of mono-(2-ethylhexyl) phthalate on blastomere-derived embryonic stem cells and differentiating neurons.

Lim, Chun Kyu; Kim, Suel-Kee; Ko, Duck Sung; Cho, Jea Won; Jun, Jin Hyun; An, Su-Yeon; Han, Jung Ho; Kim, Jong-Hoon; Yoon, Yong-Dal

Lim, Chun Kyu; Kim, Suel-Kee; Ko, Duck Sung; Cho, Jea Won; Jun, Jin Hyun; An, Su-Yeon; Han, Jung Ho; Kim, Jong-Hoon; Yoon, Yong-Dal.

Affiliation

Lim CK; Laboratory of Reproductive Endocrinology, Department of Life Science, College of Natural Sciences, Hanyang University, Seongdong-Gu, Seoul, Republic of Korea. seungzzang@paran.com

Toxicology ; 264(3): 145-54, 2009 Oct 29.

Article in En | MEDLINE | ID: mdl-19720108

Subject(s)

Blastomeres/drug effects; Cell Differentiation; Diethylhexyl Phthalate/analogs & derivatives; Embryonic Stem Cells/drug effects; Neurons/drug effects; Plasticizers/toxicity; Toxicity Tests; Animals; Apoptosis/drug effects; Blastomeres/metabolism; Blastomeres/pathology; Caspase 3/metabolism; Cell Line; Cell Survival/drug effects; DNA Fragmentation; Diethylhexyl Phthalate/toxicity; Dose-Response Relationship, Drug; Embryonic Stem Cells/metabolism; Embryonic Stem Cells/pathology; Enzyme Activation; Mice; Neurons/metabolism; Neurons/pathology; Risk Assessment; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasticizers / Blastomeres / Cell Differentiation / Toxicity Tests / Diethylhexyl Phthalate / Embryonic Stem Cells / Neurons Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Toxicology Year: 2009 Document type: Article

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