Fatty acid flux in adipocytes: the in's and out's of fat cell lipid trafficking.
Mol Cell Endocrinol
; 318(1-2): 24-33, 2010 Apr 29.
Article
in En
| MEDLINE
| ID: mdl-19720110
ABSTRACT
The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and biochemical properties that facilitate long-chain fatty acid uptake. Fatty acid efflux is initiated by hormonally controlled lipolysis of the droplet stores and produces fatty acids that must transit from their site of production to the plasma membrane and subsequently out of the cells. This review will focus on the "in's and out's" of fatty acid trafficking and summarize the current concepts in the field.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Membrane
/
Adipocytes
/
Membrane Microdomains
/
Lipid Metabolism
/
Fatty Acids
Limits:
Animals
/
Humans
Language:
En
Journal:
Mol Cell Endocrinol
Year:
2010
Document type:
Article
Affiliation country:
United States