Protection of mice against encephalomyocarditis virus infection by chemically modified transfer RNAs.
J Gen Virol
; 36(2): 351-5, 1977 Aug.
Article
in En
| MEDLINE
| ID: mdl-197205
ABSTRACT
Periodate or nitrous acid treatment greatly decreases the ability of unfractionated Escherichia coli transfer RNA (tRNA) to be aminoacylated by tRNA-synthetases but these treatments do not affect their antiviral activity against encephalomyocarditis virus infection of mice. Bisulphite treatment of E. coli tRNA reduces its ability to be aminoacylated by 20% and has no effect on antiviral activity. Bromine water treatment of tRNA under conditions causing extensive base modifications eliminates aminoacylation and the antiviral activity of E. coli tRNA. Periodate treatment of yeast tRNA does not affect its antiviral activity and nitrous acid treatment increases its antiviral activity to that of E. coli tRNA. The ability to be aminoacylated does not therefore appear to be essential for antiviral activity of tRNA but extensive modification (bromine water treatment) does destroy antiviral activity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA, Bacterial
/
RNA, Transfer
/
Enterovirus Infections
/
Escherichia coli
Limits:
Animals
Language:
En
Journal:
J Gen Virol
Year:
1977
Document type:
Article