An enriched environment restores normal behavior while providing cytoskeletal restoration and synaptic changes in the hippocampus of rats exposed to an experimental model of depression.

Sifonios, L; Trinchero, M; Cereseto, M; Ferrero, A; Cladouchos, M L; Macedo, G F; Reinés, A; Wikinski, S

Sifonios, L; Trinchero, M; Cereseto, M; Ferrero, A; Cladouchos, M L; Macedo, G F; Reinés, A; Wikinski, S.

Affiliation

Sifonios L; Instituto de Investigaciones Farmacológicas (ININFA-UBA/CONICET), Junín 956, 5 degrees piso, (1113) Ciudad de Buenos Aires, Argentina. lsifonios@ffyb.uba.ar

Neuroscience ; 164(3): 929-40, 2009 Dec 15.

Article in En | MEDLINE | ID: mdl-19729049

Subject(s)

Cytoskeleton/metabolism; Depressive Disorder/metabolism; Depressive Disorder/therapy; Environment, Controlled; Hippocampus/metabolism; Synapses/metabolism; Animals; Bromodeoxyuridine; Cytoskeleton/ultrastructure; Depressive Disorder/physiopathology; Disease Models, Animal; Disks Large Homolog 4 Protein; Exploratory Behavior/physiology; Helplessness, Learned; Hippocampus/ultrastructure; Immunohistochemistry; Intracellular Signaling Peptides and Proteins/metabolism; Male; Membrane Proteins/metabolism; Neurofilament Proteins/metabolism; Neurogenesis; Neuronal Plasticity/physiology; Neurons/metabolism; Neurons/ultrastructure; Rats; Rats, Wistar; Synapses/ultrastructure; Synaptic Transmission/physiology; Synaptophysin/metabolism; Tubulin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Cytoskeleton / Depressive Disorder / Environment, Controlled / Hippocampus Limits: Animals Language: En Journal: Neuroscience Year: 2009 Document type: Article Affiliation country: Argentina Country of publication: United States

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