The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.

Greggio, Elisa; Taymans, Jean-Marc; Zhen, Eugene Yuejun; Ryder, John; Vancraenenbroeck, Renée; Beilina, Alexandra; Sun, Peng; Deng, Junpeng; Jaffe, Howard; Baekelandt, Veerle; Merchant, Kalpana; Cookson, Mark R

Greggio, Elisa; Taymans, Jean-Marc; Zhen, Eugene Yuejun; Ryder, John; Vancraenenbroeck, Renée; Beilina, Alexandra; Sun, Peng; Deng, Junpeng; Jaffe, Howard; Baekelandt, Veerle; Merchant, Kalpana; Cookson, Mark R.

Affiliation

Greggio E; Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892-3707, USA.

Biochem Biophys Res Commun ; 389(3): 449-54, 2009 Nov 20.

Article in En | MEDLINE | ID: mdl-19733152

Subject(s)

GTP Phosphohydrolases/metabolism; Parkinson Disease/enzymology; Protein Serine-Threonine Kinases/metabolism; Amino Acid Sequence; Cell Line; GTP Phosphohydrolases/genetics; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Molecular Sequence Data; Mutation; Parkinson Disease/genetics; Phosphorylation; Protein Serine-Threonine Kinases/genetics; Protein Structure, Tertiary/genetics; Threonine/genetics; Threonine/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Protein Serine-Threonine Kinases / GTP Phosphohydrolases Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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