An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression.

Desgrosellier, Jay S; Barnes, Leo A; Shields, David J; Huang, Miller; Lau, Steven K; Prévost, Nicolas; Tarin, David; Shattil, Sanford J; Cheresh, David A

Desgrosellier, Jay S; Barnes, Leo A; Shields, David J; Huang, Miller; Lau, Steven K; Prévost, Nicolas; Tarin, David; Shattil, Sanford J; Cheresh, David A.

Affiliation

Desgrosellier JS; Department of Pathology, Moores University of California-San Diego Cancer Center, La Jolla, California, USA.

Nat Med ; 15(10): 1163-9, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19734908

Subject(s)

Integrin alphaVbeta3/metabolism; Protein-Tyrosine Kinases/metabolism; Animals; Apoptosis/physiology; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; CSK Tyrosine-Protein Kinase; Carcinoma/metabolism; Carcinoma/pathology; Cell Adhesion/physiology; Cell Proliferation; Female; Fibronectins/metabolism; Focal Adhesion Protein-Tyrosine Kinases/metabolism; Green Fluorescent Proteins/metabolism; Humans; In Situ Nick-End Labeling/methods; Ki-67 Antigen/metabolism; Lymphatic Metastasis; Mice; Mice, Nude; Neoplasm Invasiveness; Pancreatic Neoplasms/metabolism; Pancreatic Neoplasms/pathology; RNA, Small Interfering/metabolism; Substrate Specificity; Time Factors; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured; src-Family Kinases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Integrin alphaVbeta3 Limits: Animals / Female / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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