5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).

Hutchinson, John H; Li, Yiwei; Arruda, Jeannie M; Baccei, Christopher; Bain, Gretchen; Chapman, Charles; Correa, Lucia; Darlington, Janice; King, Christopher D; Lee, Catherine; Lorrain, Dan; Prodanovich, Pat; Rong, Haojing; Santini, Angelina; Stock, Nicholas; Prasit, Peppi; Evans, Jilly F

Hutchinson, John H; Li, Yiwei; Arruda, Jeannie M; Baccei, Christopher; Bain, Gretchen; Chapman, Charles; Correa, Lucia; Darlington, Janice; King, Christopher D; Lee, Catherine; Lorrain, Dan; Prodanovich, Pat; Rong, Haojing; Santini, Angelina; Stock, Nicholas; Prasit, Peppi; Evans, Jilly F.

Affiliation

Hutchinson JH; Departments of Chemistry, Amira Pharmaceuticals, San Diego, California 92121, USA. john.hutchinson@amirapharm.com

J Med Chem ; 52(19): 5803-15, 2009 Oct 08.

Article in En | MEDLINE | ID: mdl-19739647

Subject(s)

Carrier Proteins/antagonists & inhibitors; Indoles/pharmacokinetics; Leukotriene B4/antagonists & inhibitors; Membrane Proteins/antagonists & inhibitors; Propionates/pharmacokinetics; 5-Lipoxygenase-Activating Proteins; Animals; Asthma/drug therapy; Dogs; Drug-Related Side Effects and Adverse Reactions; Heterocyclic Compounds/chemistry; Humans; Inhibitory Concentration 50; Leukotriene B4/biosynthesis; Mice; Protein Binding; Rats; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propionates / Carrier Proteins / Leukotriene B4 / Indoles / Membrane Proteins Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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