Cholesterol, regulated exocytosis and the physiological fusion machine.
Biochem J
; 423(1): 1-14, 2009 Sep 14.
Article
in En
| MEDLINE
| ID: mdl-19740078
ABSTRACT
Exocytosis is a highly conserved and essential process. Although numerous proteins are involved throughout the exocytotic process, the defining membrane fusion step appears to occur through a lipid-dominated mechanism. Here we review and integrate the current literature on protein and lipid roles in exocytosis, with emphasis on the multiple roles of cholesterol in exocytosis and membrane fusion, in an effort to promote a more molecular systems-level view of the as yet poorly understood process of Ca2+-triggered membrane mergers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cholesterol
/
Exocytosis
/
Membrane Fusion
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochem J
Year:
2009
Document type:
Article
Affiliation country:
Canada