Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.

Haque, Tasir S; Liang, Ningning; Golla, Rajasree; Seethala, Ramakrishna; Ma, Zhengping; Ewing, William R; Cooper, Christopher B; Pelleymounter, Mary Ann; Poss, Michael A; Cheng, Dong

Haque, Tasir S; Liang, Ningning; Golla, Rajasree; Seethala, Ramakrishna; Ma, Zhengping; Ewing, William R; Cooper, Christopher B; Pelleymounter, Mary Ann; Poss, Michael A; Cheng, Dong.

Affiliation

Haque TS; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543-4000, USA. tasir.haque@bms.com

Bioorg Med Chem Lett ; 19(20): 5872-6, 2009 Oct 15.

Article in En | MEDLINE | ID: mdl-19740659

Subject(s)

Anti-Obesity Agents/chemistry; Enzyme Inhibitors/chemistry; Pyridines/chemistry; Acetyl-CoA Carboxylase/antagonists & inhibitors; Acetyl-CoA Carboxylase/metabolism; Anti-Obesity Agents/chemical synthesis; Anti-Obesity Agents/pharmacology; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Humans; Pyridines/chemical synthesis; Pyridines/pharmacology; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Anti-Obesity Agents / Enzyme Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United kingdom

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