ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.

Lee, Seung-Yon; Gong, Eun-Yeung; Hong, Cheol Yi; Kim, Keon-Hee; Han, Jung-Soo; Ryu, Jae Chun; Chae, Ho Zoon; Yun, Chul-Ho; Lee, Keesook

Lee, Seung-Yon; Gong, Eun-Yeung; Hong, Cheol Yi; Kim, Keon-Hee; Han, Jung-Soo; Ryu, Jae Chun; Chae, Ho Zoon; Yun, Chul-Ho; Lee, Keesook.

Affiliation

Lee SY; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, Republic of Korea.

Free Radic Biol Med ; 47(11): 1591-600, 2009 Dec 01.

Article in En | MEDLINE | ID: mdl-19751824

Subject(s)

Leydig Cells/metabolism; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism; Proto-Oncogene Proteins c-jun/metabolism; Steroids/biosynthesis; Aging/pathology; Aging/physiology; Animals; Anthracenes/pharmacology; Cell Line, Tumor; Cloning, Molecular; Gene Expression Regulation, Enzymologic; Hydrogen Peroxide/pharmacology; Leydig Cells/drug effects; Leydig Cells/pathology; MAP Kinase Kinase 4/antagonists & inhibitors; MAP Kinase Kinase 4/genetics; Male; Mice; Mutation; Oxidative Stress; Phosphoproteins/biosynthesis; Phosphoproteins/genetics; Protein Binding; Proto-Oncogene Proteins c-jun/genetics; RNA, Small Interfering/genetics; Reactive Oxygen Species/metabolism; Signal Transduction; Steroid 17-alpha-Hydroxylase/biosynthesis; Steroid 17-alpha-Hydroxylase/genetics; Transcriptional Activation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Steroids / Proto-Oncogene Proteins c-jun / Nuclear Receptor Subfamily 4, Group A, Member 1 / Leydig Cells Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2009 Document type: Article

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