Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.
Inflamm Res
; 59(2): 159-64, 2010 Feb.
Article
in En
| MEDLINE
| ID: mdl-19757086
ABSTRACT
OBJECTIVE:
We investigated the association between systemic lupus erythematosus (SLE) and polymorphisms of interleukin-23 receptor (IL23R) gene, which was recently found to be associated with autoimmune diseases, including Crohn's disease, rheumatoid arthritis, psoriasis and ankylosing spondylitis.SUBJECTS:
We analysed 383 SLE patients and 253 controls for rs11805303, rs10889677, rs1004819, rs2201841, rs11209032, 11209026, rs10489629, rs7517847 and rs7530511 variants.METHODS:
The analysis was carried out using PCR-RFLP methods. Logistic regression analysis was used to compare the genotype distributions of the polymorphisms and haplotypes between the SLE patients and healthy controls.RESULTS:
We observed no significant difference of the examined variants between the patient and control groups.CONCLUSIONS:
Our results suggest that neither single nucleotide variants nor haplotypes of IL23R indicate susceptibility to developing SLE in the Hungarian population.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Interleukin
/
Polymorphism, Single Nucleotide
/
Lupus Erythematosus, Systemic
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Inflamm Res
Journal subject:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Year:
2010
Document type:
Article
Affiliation country:
Hungary