Defining origins of malignant B cells: a new circulating normal human IgM(+)D(+) B-cell subset lacking CD27 expression and displaying somatically mutated IGHV genes as a relevant memory population.

Weston-Bell, N; Townsend, M; Di Genova, G; Forconi, F; Sahota, S S

Weston-Bell, N; Townsend, M; Di Genova, G; Forconi, F; Sahota, S S.

Affiliation

Weston-Bell N; Cancer Sciences Division, School of Medicine, University of Southampton, Southampton, UK.

Leukemia ; 23(11): 2075-80, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19776762

Subject(s)

B-Lymphocyte Subsets/immunology; Immunoglobulin Heavy Chains/genetics; Immunologic Memory/genetics; Leukemia, Hairy Cell/immunology; Somatic Hypermutation, Immunoglobulin/genetics; Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Antigens, CD19/metabolism; B-Lymphocyte Subsets/cytology; B-Lymphocyte Subsets/metabolism; Cell Lineage/immunology; Flow Cytometry; Humans; Immunoglobulin D/metabolism; Immunoglobulin M/metabolism; Immunologic Memory/immunology; Leukemia, B-Cell/genetics; Leukemia, B-Cell/immunology; Leukemia, B-Cell/pathology; Leukemia, Hairy Cell/genetics; Leukemia, Hairy Cell/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Hairy Cell / B-Lymphocyte Subsets / Immunoglobulin Heavy Chains / Tumor Necrosis Factor Receptor Superfamily, Member 7 / Somatic Hypermutation, Immunoglobulin / Immunologic Memory Type of study: Prognostic_studies Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2009 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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