Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death.

Gonfloni, Stefania; Di Tella, Lucia; Caldarola, Sara; Cannata, Stefano M; Klinger, Francesca G; Di Bartolomeo, Claudia; Mattei, Maurizio; Candi, Eleonora; De Felici, Massimo; Melino, Gerry; Cesareni, Gianni

Gonfloni, Stefania; Di Tella, Lucia; Caldarola, Sara; Cannata, Stefano M; Klinger, Francesca G; Di Bartolomeo, Claudia; Mattei, Maurizio; Candi, Eleonora; De Felici, Massimo; Melino, Gerry; Cesareni, Gianni.

Affiliation

Gonfloni S; Department of Biology, University of Rome Tor Vergata, Rome, Italy. stefania.gonfloni@uniroma2.it

Nat Med ; 15(10): 1179-85, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19783996

Subject(s)

Apoptosis/drug effects; Genes, abl/drug effects; Oocytes/metabolism; Phosphoproteins/antagonists & inhibitors; Trans-Activators/antagonists & inhibitors; Animals; Benzamides; Cell Death/drug effects; Cells, Cultured; Cisplatin/pharmacology; Cross-Linking Reagents/pharmacology; DNA Repair/drug effects; Dose-Response Relationship, Drug; Female; Imatinib Mesylate; In Situ Nick-End Labeling; Mice; Phosphorylation/drug effects; Piperazines/pharmacology; Protein Kinase Inhibitors/pharmacology; Pyrimidines/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Phosphoproteins / Trans-Activators / Genes, abl / Apoptosis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2009 Document type: Article Affiliation country: Italy Country of publication: United States

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