Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.

Hutchinson, M R; Ramos, K M; Loram, L C; Wieseler, J; Sholar, P W; Kearney, J J; Lewis, M T; Crysdale, N Y; Zhang, Y; Harrison, J A; Maier, S F; Rice, K C; Watkins, L R

Hutchinson, M R; Ramos, K M; Loram, L C; Wieseler, J; Sholar, P W; Kearney, J J; Lewis, M T; Crysdale, N Y; Zhang, Y; Harrison, J A; Maier, S F; Rice, K C; Watkins, L R.

Affiliation

Hutchinson MR; Department of Psychology and The Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.

Neuroscience ; 164(4): 1821-32, 2009 Dec 29.

Article in En | MEDLINE | ID: mdl-19788917

Subject(s)

HSP90 Heat-Shock Proteins/physiology; Pain/physiopathology; Toll-Like Receptor 4/physiology; Analgesics, Opioid/pharmacology; Animals; Benzoquinones/pharmacology; Constriction, Pathologic/complications; Dimethyl Sulfoxide/pharmacology; HSP90 Heat-Shock Proteins/antagonists & inhibitors; HSP90 Heat-Shock Proteins/biosynthesis; Injections, Spinal; Interleukin-1/antagonists & inhibitors; Lactams, Macrocyclic/pharmacology; Lipopolysaccharides/pharmacology; Male; Microglia/physiology; Morphine/pharmacology; Pain/etiology; Peripheral Nervous System Diseases/etiology; Peripheral Nervous System Diseases/physiopathology; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve/physiopathology; Signal Transduction; Toll-Like Receptor 4/agonists

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / HSP90 Heat-Shock Proteins / Toll-Like Receptor 4 Type of study: Etiology_studies Limits: Animals Language: En Journal: Neuroscience Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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