Basal ganglia neuroprotection with anticonvulsants after energy stress: a comparative study.
Metab Brain Dis
; 24(3): 453-61, 2009 Sep.
Article
in En
| MEDLINE
| ID: mdl-19789969
ABSTRACT
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model provides a valuable paradigm of the energy deficiency disorders found in childhood. In such disorders, anticonvulsants may provide neuroprotection by modulating cellular energy consumption and by exerting favorable pleiotropic effects on neuronal survival. To verify such hypothesis, we tested the effects of levetiracetam, vigabatrin, gabapentine, pregabaline, tiagabine, clonazepam and lamotrigine on neuroprotection in the MPTP mouse model. The membrane dopamine transporter (DAT) density, which provides a reliable index of dopaminergic neurons survival in the basal ganglia, was assessed by semi-quantitative autoradiography of the striatum. Unlike all other anticonvulsants tested, lamotrigine provided a significant and dose-dependent neuroprotection in these experimental conditions. Lamotrigine, a widely used and well-tolerated molecule in children, could provide neuroprotection in various energy deficiency disorders.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Basal Ganglia
/
Basal Ganglia Diseases
/
Neuroprotective Agents
/
MPTP Poisoning
/
Energy Metabolism
/
Anticonvulsants
Limits:
Animals
Language:
En
Journal:
Metab Brain Dis
Journal subject:
CEREBRO
/
METABOLISMO
Year:
2009
Document type:
Article
Affiliation country:
France