Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan.

Bonn, Britta; Masimirembwa, Collen M; Castagnoli, Neal

Bonn, Britta; Masimirembwa, Collen M; Castagnoli, Neal.

Affiliation

Bonn B; Department of Chemistry, Medicinal Chemistry, University of Gothenburg, Gothenburg, Sweden. kjelland@chem.gu.se

Drug Metab Dispos ; 38(1): 187-99, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19797609

Subject(s)

Biocatalysis; Cytochrome P-450 CYP2D6/metabolism; Cytochrome P-450 CYP3A/metabolism; Levallorphan/metabolism; Levorphanol/metabolism; Catalytic Domain; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6/chemistry; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A/chemistry; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Glutathione/metabolism; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Levallorphan/analogs & derivatives; Levallorphan/analysis; Levallorphan/chemistry; Levorphanol/analogs & derivatives; Levorphanol/analysis; Levorphanol/chemistry; Models, Chemical; Models, Molecular; Molecular Structure; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Spectrometry, Mass, Electrospray Ionization; Static Electricity; Tandem Mass Spectrometry; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 CYP2D6 / Cytochrome P-450 CYP3A / Biocatalysis / Levallorphan / Levorphanol Type of study: Prognostic_studies Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2010 Document type: Article Affiliation country: Sweden Country of publication: United States

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