Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.

Spallarossa, Paolo; Altieri, Paola; Aloi, Concetta; Garibaldi, Silvano; Barisione, Chiara; Ghigliotti, Giorgio; Fugazza, Giuseppina; Barsotti, Antonio; Brunelli, Claudio

Spallarossa, Paolo; Altieri, Paola; Aloi, Concetta; Garibaldi, Silvano; Barisione, Chiara; Ghigliotti, Giorgio; Fugazza, Giuseppina; Barsotti, Antonio; Brunelli, Claudio.

Affiliation

Spallarossa P; Research Center of Cardiovascular Biology, Division of Cardiology, University of Genoa, Viale Benedetto XV, 6, 16132 Genoa, Italy.

Am J Physiol Heart Circ Physiol ; 297(6): H2169-81, 2009 Dec.

Article in En | MEDLINE | ID: mdl-19801496

Subject(s)

Antibiotics, Antineoplastic/toxicity; Apoptosis/drug effects; Cellular Senescence/drug effects; Doxorubicin/toxicity; Myocytes, Cardiac/drug effects; Telomeric Repeat Binding Protein 1/metabolism; Telomeric Repeat Binding Protein 2/metabolism; Animals; Animals, Newborn; Anthracenes/pharmacology; Benzothiazoles/pharmacology; Cells, Cultured; Checkpoint Kinase 2; Cytoskeleton/drug effects; Cytoskeleton/metabolism; Dose-Response Relationship, Drug; Imidazoles/pharmacology; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors; JNK Mitogen-Activated Protein Kinases/metabolism; Mitosis/drug effects; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Phenotype; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Pyridines/pharmacology; RNA Interference; Rats; Rats, Sprague-Dawley; Telomeric Repeat Binding Protein 1/genetics; Telomeric Repeat Binding Protein 2/genetics; Time Factors; Toluene/analogs & derivatives; Toluene/pharmacology; Tumor Suppressor Protein p53/antagonists & inhibitors; Tumor Suppressor Protein p53/metabolism; bcl-2-Associated X Protein/metabolism; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Cellular Senescence / Apoptosis / Myocytes, Cardiac / Telomeric Repeat Binding Protein 1 / Telomeric Repeat Binding Protein 2 / Antibiotics, Antineoplastic Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2009 Document type: Article Affiliation country: Italy Country of publication: United States

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