Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice.

Carbrey, Jennifer M; Song, Linhua; Zhou, Yao; Yoshinaga, Masafumi; Rojek, Aleksandra; Wang, Yiding; Liu, Yangjian; Lujan, Heidi L; DiCarlo, Stephen E; Nielsen, Søren; Rosen, Barry P; Agre, Peter; Mukhopadhyay, Rita

Carbrey, Jennifer M; Song, Linhua; Zhou, Yao; Yoshinaga, Masafumi; Rojek, Aleksandra; Wang, Yiding; Liu, Yangjian; Lujan, Heidi L; DiCarlo, Stephen E; Nielsen, Søren; Rosen, Barry P; Agre, Peter; Mukhopadhyay, Rita.

Affiliation

Carbrey JM; Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA. jennifer.carbrey@duke.edu

Proc Natl Acad Sci U S A ; 106(37): 15956-60, 2009 Sep 15.

Article in En | MEDLINE | ID: mdl-19805235

Subject(s)

Aquaporins/deficiency; Arsenic/pharmacokinetics; Arsenic/toxicity; Animals; Aquaporins/genetics; Aquaporins/metabolism; Arsenites/pharmacokinetics; Arsenites/toxicity; Electrocardiography; Heart Conduction System/drug effects; Heart Conduction System/physiopathology; Immunohistochemistry; Lethal Dose 50; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium/metabolism; Sodium Compounds/pharmacokinetics; Sodium Compounds/toxicity; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arsenic / Aquaporins Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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