Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML.

Powell, Jason A; Thomas, Daniel; Barry, Emma F; Kok, Chung H; McClure, Barbara J; Tsykin, Anna; To, L Bik; Brown, Anna; Lewis, Ian D; Herbert, Kirsten; Goodall, Gregory J; Speed, Terence P; Asou, Norio; Jacob, Bindya; Osato, Motomi; Haylock, David N; Nilsson, Susan K; D'Andrea, Richard J; Lopez, Angel F; Guthridge, Mark A

Powell, Jason A; Thomas, Daniel; Barry, Emma F; Kok, Chung H; McClure, Barbara J; Tsykin, Anna; To, L Bik; Brown, Anna; Lewis, Ian D; Herbert, Kirsten; Goodall, Gregory J; Speed, Terence P; Asou, Norio; Jacob, Bindya; Osato, Motomi; Haylock, David N; Nilsson, Susan K; D'Andrea, Richard J; Lopez, Angel F; Guthridge, Mark A.

Affiliation

Powell JA; Cell Growth and Differentiation Laboratory, Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, SA 5000, Australia.

Blood ; 114(23): 4859-70, 2009 Nov 26.

Article in En | MEDLINE | ID: mdl-19805619

Subject(s)

Gene Expression Profiling; Hematopoietic Stem Cells/metabolism; Leukemia, Myeloid/genetics; Neoplasm Proteins/physiology; Osteopontin/physiology; Adult; Aged; Cell Survival; Cytokine Receptor Common beta Subunit/metabolism; Female; Gene Expression Regulation, Leukemic; Gene Knockdown Techniques; Gene Regulatory Networks; Hematopoietic Stem Cells/drug effects; Hematopoietic Stem Cells/pathology; Humans; Leukemia, Myeloid/metabolism; Leukemia, Myeloid/mortality; Leukemia, Myeloid/pathology; Male; Middle Aged; Neoplasm Proteins/genetics; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Osteopontin/biosynthesis; Osteopontin/genetics; Phosphatidylinositol 3-Kinases/physiology; Phosphoinositide-3 Kinase Inhibitors; Phosphoserine/metabolism; Prognosis; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; RNA, Neoplasm/biosynthesis; RNA, Neoplasm/genetics; RNA, Small Interfering/pharmacology; Signal Transduction/genetics; Tumor Cells, Cultured/drug effects; Tumor Cells, Cultured/metabolism; Tumor Cells, Cultured/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Leukemia, Myeloid / Gene Expression Profiling / Osteopontin / Neoplasm Proteins Type of study: Prognostic_studies Language: En Journal: Blood Year: 2009 Document type: Article Affiliation country: Australia Country of publication: United States

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