Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis.

López-Sánchez, Laura M; Corrales, Fernando J; Barcos, Montserrat; Espejo, Isabel; Muñoz-Castañeda, Juan R; Rodríguez-Ariza, Antonio

López-Sánchez, Laura M; Corrales, Fernando J; Barcos, Montserrat; Espejo, Isabel; Muñoz-Castañeda, Juan R; Rodríguez-Ariza, Antonio.

Affiliation

López-Sánchez LM; Unidad de Investigación del Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica, Córdoba 14004, Spain.

Lab Invest ; 90(1): 116-27, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19806079

Subject(s)

Cholestasis/metabolism; Homeostasis/drug effects; Liver/metabolism; Liver/pathology; Nitric Oxide/antagonists & inhibitors; S-Nitrosothiols/metabolism; ATP-Binding Cassette Transporters/antagonists & inhibitors; Aldehyde Oxidoreductases/antagonists & inhibitors; Aldehyde Oxidoreductases/genetics; Animals; Bile Ducts; Cholagogues and Choleretics/pharmacology; Cholestasis/etiology; Cholestasis/pathology; Down-Regulation; Enzyme Inhibitors/pharmacology; Isothiuronium/analogs & derivatives; Isothiuronium/pharmacology; Ligation; Male; Nitric Oxide/biosynthesis; Nitric Oxide/blood; Nitrosation/drug effects; Proteins/metabolism; RNA, Messenger/metabolism; Rats; Rats, Wistar; Taurochenodeoxycholic Acid/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholestasis / S-Nitrosothiols / Homeostasis / Liver / Nitric Oxide Type of study: Etiology_studies Limits: Animals Language: En Journal: Lab Invest Year: 2010 Document type: Article Affiliation country: Spain Country of publication: United States

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