Effects of administration of intravenous naloxone on gas exchange in brain-dead lung donors.
Prog Transplant
; 19(3): 267-71, 2009 Sep.
Article
in En
| MEDLINE
| ID: mdl-19813490
ABSTRACT
OBJECTIVE:
To observe the effect of naloxone on the lung function of potential lung transplant donors with neurogenic pulmonary edema. DESIGN ANDINTERVENTIONS:
Donors aged 16 to 55 years without any factors to contraindicate lung donation (pneumonia, pulmonary contusion, etc) were included. Ventilator settings were standardized to a tidal volume of 10 to 12 mL/kg, an FIO2 of 0.40, and a respiratory rate that kept PCO2 between 35 and 45 mm Hg. Chest physiotherapy, nebulizer treatments, and frequent suctioning were undertaken. Baseline arterial blood gas analysis and an oxygen challenge were performed. The patients were then given 8 to 10 mg of naloxone. Oxygen challenges and arterial blood gas analyses were repeated every 4 to 6 hours. The data were analyzed by using a paired t test, and each patient served as his or her own control.SETTING:
These interventions were performed on the 19 LifeQuest donors who met the set criteria from July 2002 to July 2004.RESULTS:
The PaO2 on the oxygen challenge immediately after administration of naloxone increased from 329 (SD 177) to 363 (SD 191) mm Hg, although the increase from baseline was not significant. The PaO2 from the second oxygen challenge (median time, 7 hours after administration of naloxone) increased to 413 (SD 177) mm Hg (P<.01).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tissue Donors
/
Brain Death
/
Pulmonary Gas Exchange
/
Lung Transplantation
/
Naloxone
/
Narcotic Antagonists
Type of study:
Observational_studies
Limits:
Adolescent
/
Adult
/
Humans
/
Middle aged
Language:
En
Journal:
Prog Transplant
Journal subject:
ENFERMAGEM
/
TRANSPLANTE
Year:
2009
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA