Pancytopenia associated with levetiracetam treatment.
Clin Drug Investig
; 29(11): 747-51, 2009.
Article
in En
| MEDLINE
| ID: mdl-19813778
ABSTRACT
Levetiracetam is a pyrrolidine derivate that is approved for the treatment of seizures. It has a favourable pharmacokinetic profile, no clearly established pharmacological interactions, good tolerability and offers the possibility of rapid treatment. We describe a case of pancytopenia and multiple infections observed in the context of levetiracetam treatment. A 65-year-old woman who underwent surgical removal of a meningioma developed progressive pancytopenia complicated by pneumonia and multiple liver abscesses after starting levetiracetam therapy. Bone marrow aspiration and biopsy confirmed the diagnosis. A gradual spontaneous recovery of normal haematopoiesis followed discontinuation of levetiracetam.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancytopenia
/
Piracetam
/
Anticonvulsants
Type of study:
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
Clin Drug Investig
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2009
Document type:
Article
Affiliation country:
Italy