Dynamic regulation of the endocannabinoid system: implications for analgesia.
Mol Pain
; 5: 59, 2009 Oct 08.
Article
in En
| MEDLINE
| ID: mdl-19814807
ABSTRACT
The analgesic effects of cannabinoids are well documented, but these are often limited by psychoactive side-effects. Recent studies indicate that the endocannabinoid system is dynamic and altered under different pathological conditions, including pain states. Changes in this receptor system include altered expression of receptors, differential synthetic pathways for endocannabinoids are expressed by various cell types, multiple pathways of catabolism and the generation of biologically active metabolites, which may be engaged under different conditions. This review discusses the evidence that pain states alter the endocannabinoid receptor system at key sites involved in pain processing and how these changes may inform the development of cannabinoid-based analgesics.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endocannabinoids
/
Cannabinoid Receptor Modulators
/
Analgesia
Limits:
Animals
/
Humans
Language:
En
Journal:
Mol Pain
Journal subject:
BIOLOGIA MOLECULAR
/
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2009
Document type:
Article
Affiliation country:
United kingdom