Distribution of heme oxygenase-2 and NADPH-diaphorase in the spinal trigeminal nucleus of the rat.
J Mol Histol
; 40(3): 209-15, 2009 Jun.
Article
in En
| MEDLINE
| ID: mdl-19821077
ABSTRACT
Heme oxygenase (HO)/carbon monoxide (CO) and nitric oxide synthase (NOS)/nitric oxide (NO) systems are involved in sensory information processing. The present study was undertaken to examine the distribution of HO-2 and NOS in the spinal trigeminal nucleus (STN) of the rat, using histochemistry and immunohistochemistry. Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining was found that NADPH-d activity was more prominent in the nucleus caudalis (Vc) and the dorsomedial subdivision of the nucleus oralis (Vo) than in other spinal trigeminal regions. Immunohistochemistry for HO-2 revealed that HO-2 staining neurons distributed extensively, which intensity was higher in the rostral than caudal part of the STN. The colocalization of NADPH-d and HO-2 was mainly confined in the Vc. The expression and distribution of NADPH-d and HO-2 suggest that NO and CO are likely neurotransmitters and might function in the processing orofacial signal in the STN together.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trigeminal Nucleus, Spinal
/
Heme Oxygenase (Decyclizing)
/
NADPH Dehydrogenase
Limits:
Animals
Language:
En
Journal:
J Mol Histol
Journal subject:
HISTOCITOQUIMICA
Year:
2009
Document type:
Article
Affiliation country:
China