Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety.

Shaw, Simon J; Chen, Yue; Zheng, Hao; Fu, Hong; Burlingame, Mark A; Marquez, Saul; Li, Yong; Claypool, Mark; Carreras, Christopher W; Crumb, William; Hardy, Dwight J; Myles, David C; Liu, Yaoquan

Shaw, Simon J; Chen, Yue; Zheng, Hao; Fu, Hong; Burlingame, Mark A; Marquez, Saul; Li, Yong; Claypool, Mark; Carreras, Christopher W; Crumb, William; Hardy, Dwight J; Myles, David C; Liu, Yaoquan.

Affiliation

Shaw SJ; Department of Chemistry, Kosan Biosciences, Inc., Hayward, California 94545, USA. sshaw@rigel.com

J Med Chem ; 52(21): 6851-9, 2009 Nov 12.

Article in En | MEDLINE | ID: mdl-19821563

Subject(s)

Erythromycin/analogs & derivatives; Erythromycin/chemical synthesis; Gastrointestinal Agents/chemical synthesis; Motilin/agonists; Animals; Bacteria/drug effects; Bacteria/isolation & purification; Cell Line; ERG1 Potassium Channel; Erythromycin/adverse effects; Erythromycin/pharmacology; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Gastrointestinal Agents/adverse effects; Gastrointestinal Agents/pharmacology; Humans; In Vitro Techniques; Intestines/microbiology; Microbial Sensitivity Tests; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Muscle, Smooth/physiology; Rabbits; Stereoisomerism; Structure-Activity Relationship; Tachyphylaxis

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastrointestinal Agents / Motilin / Erythromycin Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google