Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization.

Zahn, Grit; Vossmeyer, Dörte; Stragies, Roland; Wills, Margaret; Wong, Corinne G; Löffler, Karin U; Adamis, Anthony P; Knolle, Jochen

Zahn, Grit; Vossmeyer, Dörte; Stragies, Roland; Wills, Margaret; Wong, Corinne G; Löffler, Karin U; Adamis, Anthony P; Knolle, Jochen.

Affiliation

Zahn G; Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany. grit.zahn@gmx.net

Arch Ophthalmol ; 127(10): 1329-35, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19822850

Subject(s)

Aminopyridines/therapeutic use; Angiogenesis Inhibitors/therapeutic use; Choroidal Neovascularization/drug therapy; Disease Models, Animal; Integrin alpha5beta1/antagonists & inhibitors; beta-Alanine/analogs & derivatives; Aminopyridines/pharmacokinetics; Angiogenesis Inhibitors/pharmacokinetics; Animals; Choroidal Neovascularization/diagnosis; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroretinography; Female; Fibroblast Growth Factor 2/antagonists & inhibitors; Fluorescein Angiography; Injections; Macaca fascicularis; Male; Rabbits; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Vitreous Body; beta-Alanine/pharmacokinetics; beta-Alanine/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Alanine / Choroidal Neovascularization / Angiogenesis Inhibitors / Integrin alpha5beta1 / Disease Models, Animal / Aminopyridines Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Arch Ophthalmol Year: 2009 Document type: Article Affiliation country: Germany Country of publication: United States

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