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Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
Aronov, Alex M; Tang, Qing; Martinez-Botella, Gabriel; Bemis, Guy W; Cao, Jingrong; Chen, Guanjing; Ewing, Nigel P; Ford, Pamella J; Germann, Ursula A; Green, Jeremy; Hale, Michael R; Jacobs, Marc; Janetka, James W; Maltais, Francois; Markland, William; Namchuk, Mark N; Nanthakumar, Suganthini; Poondru, Srinivasu; Straub, Judy; ter Haar, Ernst; Xie, Xiaoling.
Affiliation
  • Aronov AM; Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, Massachusetts 02139-4242, USA. alex_aronov@vrtx.com
J Med Chem ; 52(20): 6362-8, 2009 Oct 22.
Article in En | MEDLINE | ID: mdl-19827834
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Drug Design / Extracellular Signal-Regulated MAP Kinases / Protein Kinase Inhibitors / Molecular Conformation Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Drug Design / Extracellular Signal-Regulated MAP Kinases / Protein Kinase Inhibitors / Molecular Conformation Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States