Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245.

Bari, Rafijul; Bell, Teresa; Leung, Wai-Hang; Vong, Queenie P; Chan, Wing Keung; Das Gupta, Neha; Holladay, Martha; Rooney, Barbara; Leung, Wing

Bari, Rafijul; Bell, Teresa; Leung, Wai-Hang; Vong, Queenie P; Chan, Wing Keung; Das Gupta, Neha; Holladay, Martha; Rooney, Barbara; Leung, Wing.

Affiliation

Bari R; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.

Blood ; 114(25): 5182-90, 2009 Dec 10.

Article in En | MEDLINE | ID: mdl-19828694

Subject(s)

Alleles; Arginine/genetics; Receptors, KIR2DL1/genetics; Arginine/metabolism; Arginine/physiology; Arrestins/genetics; Arrestins/metabolism; Cell Line, Tumor; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic/immunology; Flow Cytometry; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; HLA-C Antigens/genetics; HLA-C Antigens/metabolism; Humans; Interferon-gamma/metabolism; Killer Cells, Natural/immunology; Killer Cells, Natural/metabolism; Lysosomal-Associated Membrane Protein 1/metabolism; Microscopy, Fluorescence; Mutation; Polymorphism, Genetic; Receptors, KIR2DL1/metabolism; Receptors, KIR2DL1/physiology; Signal Transduction/immunology; Transfection; beta-Arrestin 2; beta-Arrestins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Alleles / Receptors, KIR2DL1 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Blood Year: 2009 Document type: Article Affiliation country: United States

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