Structure-activity relationship studies of manzamine A: amidation of positions 6 and 8 of the beta-carboline moiety.

Wahba, Amir E; Peng, Jiangnan; Kudrimoti, Sucheta; Tekwani, Babu L; Hamann, Mark T

Wahba, Amir E; Peng, Jiangnan; Kudrimoti, Sucheta; Tekwani, Babu L; Hamann, Mark T.

Affiliation

Wahba AE; Department of Pharmacognosy, The School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.

Bioorg Med Chem ; 17(22): 7775-82, 2009 Nov 15.

Article in En | MEDLINE | ID: mdl-19833520

Subject(s)

Amides/chemistry; Antimalarials/chemistry; Antimalarials/pharmacology; Carbazoles/chemistry; Carbazoles/pharmacology; Carbolines/chemistry; Mycobacterium avium Complex/drug effects; Administration, Oral; Animals; Antimalarials/administration & dosage; Antimalarials/therapeutic use; Carbazoles/administration & dosage; Carbazoles/therapeutic use; Carbolines/pharmacology; Carbolines/therapeutic use; Male; Mice; Mycobacterium avium Complex/growth & development; Mycobacterium avium Complex/metabolism; Plasmodium berghei/drug effects; Plasmodium berghei/growth & development; Plasmodium berghei/metabolism; Plasmodium falciparum/drug effects; Plasmodium falciparum/growth & development; Plasmodium falciparum/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbazoles / Carbolines / Mycobacterium avium Complex / Amides / Antimalarials Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United kingdom

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