TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB.

Risinger, George M; Updike, Dawn L; Bullen, Elizabeth C; Tomasek, James J; Howard, Eric W

Risinger, George M; Updike, Dawn L; Bullen, Elizabeth C; Tomasek, James J; Howard, Eric W.

Affiliation

Risinger GM; Young Blvd., Biomedical Sciences Bldg., Rm 513, Oklahoma City, OK 73104, USA.

Am J Physiol Cell Physiol ; 298(1): C191-201, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19846754

Subject(s)

Matrix Metalloproteinase 2/genetics; Muscle, Smooth, Vascular/enzymology; Platelet-Derived Growth Factor/pharmacology; Transforming Growth Factor beta1/pharmacology; Up-Regulation/drug effects; Actins/genetics; Animals; Becaplermin; DNA Primers; Down-Regulation; Gene Expression Regulation, Enzymologic/drug effects; Genes, fos; Humans; Macrophage Colony-Stimulating Factor/pharmacology; Muscle Contraction/drug effects; Muscle Contraction/physiology; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/drug effects; Polymerase Chain Reaction; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred WKY; Recombinant Proteins/pharmacology; Signal Transduction/drug effects; Signal Transduction/physiology; Tissue Inhibitor of Metalloproteinase-1/genetics; Tissue Inhibitor of Metalloproteinase-2/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platelet-Derived Growth Factor / Up-Regulation / Matrix Metalloproteinase 2 / Transforming Growth Factor beta1 / Muscle, Smooth, Vascular Limits: Animals / Humans Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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