Prednisolone prevents transient ischemia-induced cochlear damage in gerbils.
Acta Otolaryngol Suppl
; (562): 24-7, 2009 Jun.
Article
in En
| MEDLINE
| ID: mdl-19848235
CONCLUSIONS: Prednisolone protects against inner ear damage, even when administered after ischemic injury in Mongolian gerbils. OBJECTIVE: The effect of prednisolone on ischemia-induced cochlear damage was investigated in Mongolian gerbils. MATERIALS AND METHODS: The bilateral vertebral arteries were occluded for 15 min to transiently induce cochlear ischemia, followed by an intraperitoneal injection of prednisolone (1 mg/kg) or physiological saline (control). Sequential changes in hearing were evaluated by recording the auditory brainstem response (ABR) before and at 1, 4, and 7 days after treatment. In our histologic analysis, the numbers of dead and intact inner hair cells (IHCs) were counted in specimens stained with rhodamine-phalloidin. RESULTS: In control animals, transient ischemia increased the ABR threshold (24.2 +/- 8.6 dB) within 7 days of treatment, whereas prednisolone-treated animals exhibited a threshold of 14.2 +/- 9.2 dB. Furthermore, the percent IHC loss at the basal turn of the cochlea was 26.5 +/- 11.4% in control animals compared with 5.3 +/- 3.0% in the prednisolone-treated group.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prednisolone
/
Evoked Potentials, Auditory, Brain Stem
/
Cochlea
/
Glucocorticoids
/
Ischemia
Limits:
Animals
Language:
En
Journal:
Acta Otolaryngol Suppl
Year:
2009
Document type:
Article
Affiliation country:
Japan
Country of publication:
Norway