Assessment of the putative binding conformation of a pyrazolopyridine class of inhibitors of MAPKAPK2 using computational studies.

Miglani, Rajni; Cliffe, Ian A; Voleti, Sreedhara R

Miglani, Rajni; Cliffe, Ian A; Voleti, Sreedhara R.

Affiliation

Miglani R; Division of Molecular Modeling, New Drug Discovery Research, Ranbaxy Laboratories Limited, Sector-18, Gurgaon-122001, India. rajni.miglani@gmail.com

Eur J Med Chem ; 45(1): 98-105, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19850376

Subject(s)

Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Intracellular Signaling Peptides and Proteins/chemistry; Models, Molecular; Protein Kinase Inhibitors/metabolism; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/chemistry; Pyrazoles/metabolism; Pyrazoles/pharmacology; Pyridines/metabolism; Pyridines/pharmacology; Adenosine Triphosphate/metabolism; Amino Acid Motifs; Amino Acid Sequence; Catalytic Domain; Computer Simulation; Conserved Sequence; Crystallography, X-Ray; Glycine; Intracellular Signaling Peptides and Proteins/metabolism; Ligands; Protein Binding; Protein Kinase Inhibitors/chemistry; Protein Serine-Threonine Kinases/metabolism; Protein Structure, Secondary; Pyrazoles/chemistry; Pyridines/chemistry; Reproducibility of Results

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyridines / Models, Molecular / Protein Serine-Threonine Kinases / Intracellular Signaling Peptides and Proteins / Protein Kinase Inhibitors Type of study: Prognostic_studies / Qualitative_research Language: En Journal: Eur J Med Chem Year: 2010 Document type: Article Affiliation country: India Country of publication: France

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