Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.

Risseeuw, Martijn D P; van den Berg, Richard J B H N; Donker-Koopman, Wilma E; van der Marel, Gijs A; Aerts, Johannes M F G; Overhand, Mark; Overkleeft, Herman S

Risseeuw, Martijn D P; van den Berg, Richard J B H N; Donker-Koopman, Wilma E; van der Marel, Gijs A; Aerts, Johannes M F G; Overhand, Mark; Overkleeft, Herman S.

Affiliation

Risseeuw MD; Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2300 RA Leiden, The Netherlands.

Bioorg Med Chem Lett ; 19(23): 6600-3, 2009 Dec 01.

Article in En | MEDLINE | ID: mdl-19853441

Subject(s)

Amines/chemical synthesis; Amines/pharmacology; Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Glucosidases/antagonists & inhibitors; Amines/chemistry; Bridged Bicyclo Compounds, Heterocyclic/chemistry; Drug Evaluation, Preclinical; Enzyme Inhibitors/chemistry; Molecular Conformation; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bridged Bicyclo Compounds, Heterocyclic / Enzyme Inhibitors / Amines / Glucosidases Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: Netherlands

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