Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.

Fan, Xingjun; Zhang, Jianye; Theves, Mathilde; Strauch, Christopher; Nemet, Ina; Liu, Xiaoqin; Qian, Juan; Giblin, Frank J; Monnier, Vincent M

Fan, Xingjun; Zhang, Jianye; Theves, Mathilde; Strauch, Christopher; Nemet, Ina; Liu, Xiaoqin; Qian, Juan; Giblin, Frank J; Monnier, Vincent M.

Affiliation

Fan X; Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 , USA.

J Biol Chem ; 284(50): 34618-27, 2009 Dec 11.

Article in En | MEDLINE | ID: mdl-19854833

Subject(s)

Aging/physiology; Crystallins/metabolism; Diabetes Mellitus/metabolism; Lens, Crystalline/metabolism; Lysine/metabolism; 2-Aminoadipic Acid/analogs & derivatives; 2-Aminoadipic Acid/metabolism; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Cattle; Child; Crystallins/chemistry; Crystallins/genetics; Diabetes Mellitus/pathology; Humans; Hydrogen Peroxide/metabolism; Hyperbaric Oxygenation; Lens, Crystalline/chemistry; Lens, Crystalline/pathology; Leucine/chemistry; Lysine/chemistry; Metals/chemistry; Mice; Mice, Inbred C57BL; Middle Aged; Molecular Structure; Oxidants/metabolism; Oxidation-Reduction; Rabbits; Regression Analysis; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Crystallins / Diabetes Mellitus / Lens, Crystalline / Lysine Type of study: Diagnostic_studies Limits: Adolescent / Adult / Aged / Aged80 / Animals / Child / Humans / Middle aged Language: En Journal: J Biol Chem Year: 2009 Document type: Article Affiliation country: United States

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