Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.

Nickell, Justin R; Krishnamurthy, Sairam; Norrholm, Seth; Deaciuc, Gabriela; Siripurapu, Kiran B; Zheng, Guangrong; Crooks, Peter A; Dwoskin, Linda P

Nickell, Justin R; Krishnamurthy, Sairam; Norrholm, Seth; Deaciuc, Gabriela; Siripurapu, Kiran B; Zheng, Guangrong; Crooks, Peter A; Dwoskin, Linda P.

Affiliation

Nickell JR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA.

J Pharmacol Exp Ther ; 332(2): 612-21, 2010 Feb.

Article in En | MEDLINE | ID: mdl-19855096

Subject(s)

Dopamine/metabolism; Lobeline/analogs & derivatives; Methamphetamine/pharmacology; Vesicular Monoamine Transport Proteins/antagonists & inhibitors; 3,4-Dihydroxyphenylacetic Acid/metabolism; Amphetamine-Related Disorders/drug therapy; Animals; Corpus Striatum/drug effects; Dopamine Plasma Membrane Transport Proteins/antagonists & inhibitors; Drug Evaluation, Preclinical; Lobeline/pharmacology; Lobeline/therapeutic use; Male; Nicotinic Agonists/pharmacology; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Synaptic Vesicles/metabolism; Synaptosomes/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dopamine / Vesicular Monoamine Transport Proteins / Lobeline / Methamphetamine Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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