ATX-LPA receptor axis in inflammation and cancer.
Cell Cycle
; 8(22): 3695-701, 2009 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-19855166
ABSTRACT
Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G protein-coupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrophosphatases
/
Breast Neoplasms
/
Lysophospholipids
/
Signal Transduction
/
Phosphodiesterase I
/
Receptors, Lysophosphatidic Acid
/
Inflammation
/
Multienzyme Complexes
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Cell Cycle
Year:
2009
Document type:
Article
Affiliation country:
United States