R-spondin1 is required for normal epithelial morphogenesis during mammary gland development.
Biochem Biophys Res Commun
; 390(3): 1040-3, 2009 Dec 18.
Article
in En
| MEDLINE
| ID: mdl-19857464
ABSTRACT
The R-spondin (Rspo) proteins constitute a novel class of ligands that induce Wnt signalling. Rspo1 knockout XX mice were previously shown to be sex-reversed, but some remain sub-fertile. These last were unable to feed their pups for some unknown reason. Using these mice and transplanted mammary tissues from Rspo1(-/-) virgin mice in nude mice, we report that the lack of Rspo1 expression results in the absence of duct side-branching development and subsequent alveolar formation, explaining the above mentioned phenotype. Our data demonstrate that local epithelial Rspo1 signalling is required for normal development of the mammary gland.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombospondins
/
Epithelium
/
Mammary Glands, Animal
/
Morphogenesis
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2009
Document type:
Article
Affiliation country:
France