Resistance of cutaneous anaplastic large-cell lymphoma cells to apoptosis by death ligands is enhanced by CD30-mediated overexpression of c-FLIP.

Braun, Frank K; Hirsch, Burkhard; Al-Yacoub, Nadya; Dürkop, Horst; Assaf, Chalid; Kadin, Marshall E; Sterry, Wolfram; Eberle, Jürgen

Braun, Frank K; Hirsch, Burkhard; Al-Yacoub, Nadya; Dürkop, Horst; Assaf, Chalid; Kadin, Marshall E; Sterry, Wolfram; Eberle, Jürgen.

Affiliation

Braun FK; Department of Dermatology and Allergy, Charité-University Medical Center Berlin, HTCC-Skin Cancer Center, Berlin, Germany.

J Invest Dermatol ; 130(3): 826-40, 2010 Mar.

Article in En | MEDLINE | ID: mdl-19890350

Subject(s)

Apoptosis/physiology; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics; Ki-1 Antigen/metabolism; Lymphoma, Large-Cell, Anaplastic/pathology; Skin Neoplasms/pathology; Apoptosis/drug effects; BH3 Interacting Domain Death Agonist Protein/metabolism; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism; Caspases/metabolism; Cell Line, Tumor; Gene Expression Regulation, Neoplastic/drug effects; Gene Expression Regulation, Neoplastic/physiology; Humans; Ki-1 Antigen/pharmacology; Lymphoma, Large-Cell, Anaplastic/metabolism; Lymphoma, Large-Cell, Anaplastic/physiopathology; NF-kappa B/metabolism; RNA Interference; Receptor Cross-Talk/physiology; Receptors, Tumor Necrosis Factor, Type I/metabolism; Skin Neoplasms/metabolism; Skin Neoplasms/physiopathology; Up-Regulation/drug effects; Up-Regulation/physiology; fas Receptor/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Apoptosis / Lymphoma, Large-Cell, Anaplastic / Ki-1 Antigen / CASP8 and FADD-Like Apoptosis Regulating Protein Limits: Humans Language: En Journal: J Invest Dermatol Year: 2010 Document type: Article Affiliation country: Germany

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