Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis.

Paulson, Kim E; Zhu, Su-Ning; Chen, Mian; Nurmohamed, Sabrina; Jongstra-Bilen, Jenny; Cybulsky, Myron I

Paulson, Kim E; Zhu, Su-Ning; Chen, Mian; Nurmohamed, Sabrina; Jongstra-Bilen, Jenny; Cybulsky, Myron I.

Affiliation

Paulson KE; Toronto General Hospital, 200 Elizabeth St, MBRC 1R-408, Toronto ON M5G 2C4, Canada.

Circ Res ; 106(2): 383-90, 2010 Feb 05.

Article in En | MEDLINE | ID: mdl-19893012

Subject(s)

Atherosclerosis/metabolism; Dendritic Cells/metabolism; Lipids/analysis; Tunica Intima/metabolism; Animals; Aorta/metabolism; Aorta/pathology; Atherosclerosis/pathology; CD11c Antigen/genetics; CD11c Antigen/metabolism; Cholesterol, Dietary/administration & dosage; Dendritic Cells/pathology; Diphtheria Toxin; Endothelial Cells/metabolism; Endothelial Cells/pathology; Female; Foam Cells/metabolism; Foam Cells/pathology; Foam Cells/ultrastructure; Heparin-binding EGF-like Growth Factor; Hypercholesterolemia/chemically induced; Hypercholesterolemia/metabolism; Hypercholesterolemia/pathology; Immunohistochemistry; Intercellular Signaling Peptides and Proteins/genetics; Intercellular Signaling Peptides and Proteins/metabolism; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Microscopy, Electron, Transmission; Receptors, LDL/genetics; Receptors, LDL/metabolism; Tunica Intima/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Tunica Intima / Atherosclerosis / Lipids Language: En Journal: Circ Res Year: 2010 Document type: Article Affiliation country: Canada

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