Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Lv, Binhua; Xu, Baihua; Feng, Yan; Peng, Kun; Xu, Ge; Du, Jiyan; Zhang, Lili; Zhang, Wenbin; Zhang, Ting; Zhu, Liangcheng; Ding, Haifeng; Sheng, Zelin; Welihinda, Ajith; Seed, Brian; Chen, Yuanwei

Lv, Binhua; Xu, Baihua; Feng, Yan; Peng, Kun; Xu, Ge; Du, Jiyan; Zhang, Lili; Zhang, Wenbin; Zhang, Ting; Zhu, Liangcheng; Ding, Haifeng; Sheng, Zelin; Welihinda, Ajith; Seed, Brian; Chen, Yuanwei.

Affiliation

Lv B; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China. 51popo51@163.com

Bioorg Med Chem Lett ; 19(24): 6877-81, 2009 Dec 15.

Article in En | MEDLINE | ID: mdl-19896374

Subject(s)

Benzofurans/chemistry; Glucosides/chemistry; Pyrans/chemistry; Sodium-Glucose Transporter 2 Inhibitors; Spiro Compounds/chemistry; Animals; Benzofurans/pharmacology; Blood Glucose/drug effects; Glucosides/pharmacology; Glycosuria/chemically induced; Humans; Pyrans/pharmacology; Rats; Rats, Sprague-Dawley; Spiro Compounds/pharmacology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrans / Spiro Compounds / Benzofurans / Sodium-Glucose Transporter 2 Inhibitors / Glucosides Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google