Hit to lead studies on (hetero)arylpyrimidines--agonists of the canonical Wnt-beta-catenin cellular messaging system.

Gilbert, Adam M; Bursavich, Matthew G; Alon, Nippa; Bhat, Bheem M; Bex, Frederick J; Cain, Michael; Coleburn, Valerie; Gironda, Virginia; Green, Paula; Hauze, Diane B; Kharode, Yogendra; Krishnamurthy, Girija; Kirisits, Matthew; Lam, Ho-Sun; Liu, Yao-Bin; Lombardi, Sabrina; Matteo, Jeanne; Murrills, Richard; Robinson, John A; Selim, Sally; Sharp, Michael; Unwalla, Raymond; Varadarajan, Usha; Zhao, Weiguang; Yaworsky, Paul J

Gilbert, Adam M; Bursavich, Matthew G; Alon, Nippa; Bhat, Bheem M; Bex, Frederick J; Cain, Michael; Coleburn, Valerie; Gironda, Virginia; Green, Paula; Hauze, Diane B; Kharode, Yogendra; Krishnamurthy, Girija; Kirisits, Matthew; Lam, Ho-Sun; Liu, Yao-Bin; Lombardi, Sabrina; Matteo, Jeanne; Murrills, Richard; Robinson, John A; Selim, Sally; Sharp, Michael; Unwalla, Raymond; Varadarajan, Usha; Zhao, Weiguang; Yaworsky, Paul J.

Affiliation

Gilbert AM; Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, United States. gilbera@wyeth.com

Bioorg Med Chem Lett ; 20(1): 366-70, 2010 Jan 01.

Article in En | MEDLINE | ID: mdl-19897365

Subject(s)

Imidazoles/chemistry; Pyrimidines/chemistry; Wnt Proteins/metabolism; beta Catenin/metabolism; Animals; Bone Development/drug effects; Cell Line, Tumor; Glycogen Synthase Kinase 3/metabolism; Glycogen Synthase Kinase 3 beta; Humans; Imidazoles/chemical synthesis; Imidazoles/pharmacology; Intercellular Signaling Peptides and Proteins/genetics; Intercellular Signaling Peptides and Proteins/metabolism; Mice; Mice, Inbred C57BL; Pyrimidines/chemical synthesis; Pyrimidines/pharmacology; Recombinant Fusion Proteins/agonists; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Signal Transduction; Skull/metabolism; Wnt Proteins/agonists; Wnt Proteins/genetics; Wnt3 Protein; Wnt3A Protein; beta Catenin/agonists

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Wnt Proteins / Beta Catenin / Imidazoles Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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