Intermittent hepatic arterial or portal occlusion reduces liver tumor growth.
J Surg Res
; 50(2): 146-9, 1991 Feb.
Article
in En
| MEDLINE
| ID: mdl-1990219
ABSTRACT
The effect of repeated, intermittent hepatic vascular occlusion on liver tumor growth was studied in 32 rats. An adenocarcinoma was inoculated in the left liver lobe. After 8 days, the tumor size was measured and then, in three groups, the hepatic artery was occluded intermittently during 5 days for 15 min, 1 hr, or 2 hr daily, respectively. The tumor growth after 6 days in these groups was compared with that in a group where instead the portal vein was occluded intermittently during 5 days for 15 min, and with that in a group of sham-operated control rats. In the control rats, the tumor volume (mean +/- SEM) increased from 0.16 +/- 0.03 to 1.34 +/- 0.15 cm3 during the 6 days of experiment. It was found that repeated, intermittent occlusion of the hepatic artery or the portal vein, retarded the liver tumor growth to 30-60% of the growth rate in sham-operated controls (P less than or equal to 0.015). The 15-min daily hepatic artery or portal vein occlusion was found to reduce the tumor growth rate as much as daily hepatic artery occlusion for 2 hr. It is suggested that short, daily, intermittent hepatic vascular occlusions might be efficient in the palliative treatment of liver malignancy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Portal Vein
/
Adenocarcinoma
/
Colonic Neoplasms
/
Hepatic Artery
/
Liver Neoplasms
Limits:
Animals
Language:
En
Journal:
J Surg Res
Year:
1991
Document type:
Article
Affiliation country:
Sweden