The effects of exercise-induced fatigue on acetylcholinesterase expression and activity at rat neuromuscular junctions.
Acta Histochem Cytochem
; 42(5): 137-42, 2009 Oct 30.
Article
in En
| MEDLINE
| ID: mdl-19918322
ABSTRACT
Acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. Although acetylcholinesterase has been studied for almost a century, the underlying relationship between exercise-induced fatigue and acetylcholinesterase activity at the synaptic cleft is not clear. The purpose of this study was to assess the effects of exercise-induced fatigue on the expression and activity of acetylcholinesterase at the neuromuscular junctions. The expression and activity of acetylcholinesterase at the gastrocnemius neuromuscular junctions was decreased transiently by exercise-induced fatigue and then gradually increased over 24 hr. The expression of acetylcholinesterase in the 24 hr recovery group returned to the level of the control (non-exercised) group, but the activity of acetylcholinesterase remained significantly lower. These data suggest that the decrease of acetylcholinesterase expression and activity may be involved in the production and/or maintenance of exercise-induced fatigue.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Acta Histochem Cytochem
Year:
2009
Document type:
Article
Affiliation country:
China
Publication country:
JAPAN
/
JAPON
/
JAPÃO
/
JP