Daunorubicin-loaded magnetic nanoparticles of Fe3O4 overcome multidrug resistance and induce apoptosis of K562-n/VCR cells in vivo.

Chen, Bao-an; Lai, Bin-bin; Cheng, Jian; Xia, Guo-hua; Gao, Feng; Xu, Wen-lin; Ding, Jia-hua; Gao, Chong; Sun, Xin-chen; Xu, Cui-rong; Chen, Wen-ji; Chen, Ning-na; Liu, Li-jie; Li, Xiao-mao; Wang, Xue-mei

Chen, Bao-an; Lai, Bin-bin; Cheng, Jian; Xia, Guo-hua; Gao, Feng; Xu, Wen-lin; Ding, Jia-hua; Gao, Chong; Sun, Xin-chen; Xu, Cui-rong; Chen, Wen-ji; Chen, Ning-na; Liu, Li-jie; Li, Xiao-mao; Wang, Xue-mei.

Affiliation

Chen BA; Department of Hematology.

Int J Nanomedicine ; 4: 201-8, 2009.

Article in En | MEDLINE | ID: mdl-19918366

Subject(s)

Antibiotics, Antineoplastic/administration & dosage; Daunorubicin/administration & dosage; Ferrosoferric Oxide/administration & dosage; Metal Nanoparticles/administration & dosage; Animals; Base Sequence; DNA Primers/genetics; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression/drug effects; Humans; K562 Cells; Leukemia, Experimental/drug therapy; Leukemia, Experimental/genetics; Leukemia, Experimental/pathology; Magnetics; Mice; Mice, Nude; Nanomedicine; Neoplasm Transplantation; RNA, Neoplasm/genetics; Transplantation, Heterologous

Key words

in vivo; leukemia; magnetic nanoparticles of Fe3O4; multidrug-resistance reversal

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Daunorubicin / Ferrosoferric Oxide / Metal Nanoparticles / Antibiotics, Antineoplastic Limits: Animals / Female / Humans Language: En Journal: Int J Nanomedicine Year: 2009 Document type: Article Country of publication: New Zealand

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